Psoriasis Pathophysiology: Understanding Inflammation
- Immune System Dysregulation:
Normally, immune cells defend the body against infection, but in psoriasis the immune system mistakenly attacks healthy skin cells, triggering an overactive response.
- Accelerated Skin Cell Growth:
This immune misinterpretation leads to an abnormal acceleration in the production of skin cells causing them to mature rapidly and accumulate on the surface. Generally, process of skin cell turnover occurs gradually.
- Inflammation Cascade:
As these excess skin cells accumulate on the skin's surface, the immune system responds with an inflammatory response. Inflammation manifests as redness, swelling and discomfort, creating the visible symptoms associated with psoriasis.
- Cytokine Overproduction:
Cytokines, signaling molecules in the body, play a pivotal role in psoriasis. The immune misinterpretation causes an imbalance resulting in overproduction of cytokines which further exacerbates inflammation and disturbs the normal balance of skin cell growth.
- Chronic Inflammation:
The chronic inflammation not only affects the skin's appearance but also impacts its integrity. The skin barrier weakens, making it more susceptible to external irritants and contributing to the cycle of inflammation.
Conclusion:
Addressing inflammation is an important aspect of psoriasis management and anti-inflammatory actives plays a crucial role in reducing the symptoms and improving the quality of life of individuals. Whether through topical therapies such as systemic medications or dietary interventions, the goal is to modulate the immune response and reduce the inflammatory processes that cause psoriasis. As research advances, anti-inflammatory agents are likely to remain a cornerstone in a comprehensive approach to psoriasis treatment.
Our Suggestion:
We recommended you to try Psorolin - B ointment for all types of psoriasis, which is formulated with strong anti-inflammatory agents such as Boswellic acid and Red ochre. It is scientifically proven to Inhibit pro-inflammatory mediators- TNF alpha, IL-6 and IL-8.
To know about Psorolin - B ointment, click the following link: https://jrkresearch.com/collections/psoriasis/products/psorolin-b-ointment
Dr. JRK's 777 Oil is clinically proven for all types of psoriasis treatment. It decreases keratinocyte proliferation and inhibits inflammatory mediators like interleukins and cytokines.
To know about Dr. JRK's 777 Oil, click the following link: https://jrkresearch.com/collections/psoriasis/products/dr-jrks-777-oil
JRK's Psorolin Derma Skincare Soap is an advanced skin care soap with added anti-inflammatory actives such as Boswellia serrata, which effectively manages psoriasis, dry skin, fungal skin infection, vitiligo and geriatric dry skin by providing intense moisturization to the skin.
To know about JRK's Psorolin Derma Skincare Soap, click the following link: https://jrkresearch.com/collections/psoriasis/products/pdss
Allopathic medicines for psoriasis such as topical corticosteroids, immunosuppressants, methotrexate, cyclosporine or biologics may have potential side effects, including systemic issues and in some cases, they may only provide temporary relief without addressing the underlying causes or preventing long-term recurrence. Additionally, prolonged use of certain medications may lead to tolerance or dependency.
